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ABSTRACT Mediation analysis is widely utilized in neuroscience to investigate the role of brain image phenotypes in the neurological pathways from genetic exposures to clinical outcomes. However, it is still difficult to conduct mediation analyses with whole genome‐wide exposures and brain subcortical shape mediators due to several challenges including (i) large‐scale genetic exposures, that is, millions of single‐nucleotide polymorphisms (SNPs); (ii) nonlinear Hilbert space for shape mediators; and (iii) statistical inference on the direct and indirect effects. To tackle these challenges, this paper proposes a genome‐wide mediation analysis framework with brain subcortical shape mediators. First, to address the issue caused by the high dimensionality in genetic exposures, a fast genome‐wide association analysis is conducted to discover potential genetic variants with significant genetic effects on the clinical outcome. Second, the square‐root velocity function representations are extracted from the brain subcortical shapes, which fall in an unconstrained linear Hilbert subspace. Third, to identify the underlying causal pathways from the detected SNPs to the clinical outcome implicitly through the shape mediators, we utilize a shape mediation analysis framework consisting of a shape‐on‐scalar model and a scalar‐on‐shape model. Furthermore, the bootstrap resampling approach is adopted to investigate both global and spatial significant mediation effects. Finally, our framework is applied to the corpus callosum shape data from the Alzheimer's Disease Neuroimaging Initiative. 

Abstract A coronal mass ejection erupted from the Sun on 21 April 2023 and created a G4 geomagnetic storm on 23 April. NASA's global‐scale observations of the limb and disk (GOLD) imager observed bright equatorial ionization anomaly (EIA) crests at ∼25° Mlat, ∼11° poleward from their average locations, computed by averaging the EIA crests during the previous geomagnetic quiet days (18–22 April) between ∼15°W and 5°W Glon. ReversedC‐shape equatorial plasma bubbles (EPBs) were observed reaching ∼±36° Mlat (∼40°N and ∼30°S Glat) with apex altitudes ∼4,000 km and large westward tilts of ∼52°. Using GOLD's observations EPBs zonal motions are derived. It is observed that the EPBs zonal velocities are eastward near the equator and westward at mid‐latitudes. Model‐predicted prompt penetration electric fields indicate that they may have affected the postsunset pre‐reversal enhancement at equatorial latitudes. Zonal ion drifts from a defense meteorological satellite program satellite suggest that westward neutral winds and perturbed westward ion drifts over mid‐latitudes contributed to the observed latitudinal shear in zonal drifts.